Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 51 0.0 0.465 0.03 0.084
biological_process el 51 0.011 0.966 0.619 0.244
biological_process ka 51 0.0 0.443 0.028 0.078
biological_process rf 51 0.0 0.465 0.03 0.084
cellular_component ct 3 0.0 0.109 0.041 0.048
cellular_component el 3 0.0 0.738 0.247 0.347
cellular_component ka 3 0.002 0.145 0.055 0.063
cellular_component rf 3 0.0 0.109 0.041 0.048
disease ct 13 0.001 0.863 0.179 0.257
disease el 13 0.005 0.806 0.332 0.264
disease ka 13 0.0 0.942 0.192 0.283
disease rf 13 0.001 0.863 0.179 0.257
genetic_interaction ct 47 0.0 1.0 0.389 0.332
genetic_interaction el 47 0.0 1.0 0.418 0.347
genetic_interaction ka 47 0.0 1.0 0.915 0.279
genetic_interaction rf 47 0.0 1.0 0.407 0.342
molecular_function ct 4 0.0 0.0 0.0 0.0
molecular_function el 4 0.473 0.593 0.549 0.046
molecular_function ka 4 0.0 0.001 0.0 0.0
molecular_function rf 4 0.0 0.001 0.0 0.0
pathway ct 26 0.001 0.996 0.062 0.19
pathway el 26 0.001 0.207 0.02 0.042
pathway ka 26 0.001 1.0 0.273 0.441
pathway rf 26 0.001 0.168 0.022 0.039
phenotype ct 12 0.0 0.848 0.308 0.323
phenotype el 12 0.033 0.837 0.416 0.237
phenotype ka 12 0.0 0.965 0.354 0.358
phenotype rf 12 0.0 0.876 0.311 0.327
protein_interaction ct 53 0.0 0.741 0.024 0.105
protein_interaction el 53 0.0 0.779 0.027 0.111
protein_interaction ka 53 0.001 1.0 0.214 0.402
protein_interaction rf 53 0.0 0.74 0.023 0.104

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 53 0.0 0.607 0.042 0.124
integration_mean_by_presence el 53 0.0 0.849 0.045 0.141
integration_mean_by_presence ka 53 0.0 0.504 0.027 0.085
integration_mean_by_presence rf 53 0.0 0.297 0.02 0.053
mean ct 53 0.0 0.554 0.04 0.12
mean el 53 0.0 0.394 0.034 0.09
mean ka 53 0.0 0.362 0.028 0.076
mean rf 53 0.0 0.292 0.029 0.069

CDF plots of non integrated kernels

CDF plots of integrated kernels